Among microorganisms, actinobacteria and fungi remain outstanding sources of bioactive compounds with potential application to various fields. In particular, discovery and development from unexplored environments have been proved a successful strategy when pursuing for microbial novelty. Besides a wealth of information about terrestrial actinobacteria and fungi, marine environments, which represent a large part of the Earth’s biosphere, still remain mostly unexplored. Marine environments are, therefore, inspiring the search for new bioactive molecules of interest such as nutraceuticals, proteins, and pharmaceuticals for various applications.