A graduate fellow position (Assegno di Ricerca) is available at the Department of Biology of the University of Padova for the project entitled: “Investigating the role of the integral membrane protein LysX2 in Mycobacterium tuberculosis virulence”.
Starting no later than December 1st, 2022.
Duration: 18 months.

State of the Art and Research Program
We have recently identified a new gene of Mycobacterium tuberculosis (Mtb) encoding an integral membrane protein with a putative aminoacyl-phosphatidylglycerol (aaPG) synthase domain which we named LysX2 (Boldrin F. et al. BMC Microbiology 2022, 22(1):85; doi: 10.1186/s12866-022-02493-2). AaPG synthases are widely represented among prokaryotes since several bacterial species use them to produce aminoacyl esters of phosphatidylglycerol (aaPGs) which confer resistance to low pH and antimicrobial cationic peptides (CAMPs) by increasing the net positive charge of the bacterial surface.

Il Laboratorio di Fisica Ambientale al Dipartimento di Fisica di UNIGE, insieme alla sezione genovese dell'Istituto Nazionale di Fisica Nucleare (INFN), gestisce l'unica camera di simulazione atmosferica italiana (ChAMBRe, https://labfisa.ge.infn.it/index.php/chambre). Nell'ambito di programmi di ricerca europei e di progetti PNRR, il laboratorio sta conducendo una ricerca sulle possibili correlazioni tra qualità dell'aria e persistenza e diffusione aerea dei microrganismi, proprio utilizzando ChAMBre. Il gruppo di ricerca è multidisciplinare e lo si vuole completare con competenze di tipo biologico (in particolare microbiologico). Il lavoro di ricerca prevede diverse collaborazioni internazionali.

Al momento è aperto il bando per un assegno di ricerca annuale di II fascia (stipendio netto ca 1800 euro/mese), con presa di servizio al 1/10/2022 (bando e modulistica al sito: https://concorsi.unige.it/home/procedure/3391;jsessionid=A43ECD568EA8D6EB2CF54D237B379BB9), scadenza delle domande 29/7/22, requisito di accesso Laurea Magistrale in biologia o chimica.

Per maggiori informazioni e/o dettagli contattare il responsabile del Laboratorio, Prof. Paolo Prati (prati@ge.infn.it; tel: 0103536439).

APPLICATION CLOSING DATE: June 30th 2022

Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian government, with the aim of developing innovative strategies to improve human health. HT is composed of five centres: Computational Biology, Structural Biology, Genomics, Neurogenomics, and Health Data Science.
The Centres work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.
The Pinheiro Lab in the Computational Biology Research Centre at Human Technopole, led by Dr. Fernanda Pinheiro, integrates theoretical and experimental research to develop a predictive framework for evolutionary processes under ecological complexity grounded on models of cell metabolism. We are a hybrid theoretical and experimental lab with a strong interest in understanding antibiotic resistance evolution in complex ecologies including microbial communities where many bacteria interact. We combine systems biology approaches, evolutionary modeling, computational methods, data analysis, and data from evolution experiments, establishing a strong dialog between theory and experiments: We use theory to identify interesting regimes that can optimize experimental designs and biology to motivate new theoretical methods.

We are constantly looking for talented and passionate people to join our team, so even if you don’t see specific positions here, don’t be afraid to drop us an email! We can always discuss the possibility of writing a fellowship together to get to join us! Visiting positions are always possible, especially if funded though one of the many program that can support your visit here, like the Marie Skłodowska-Curie Actions and the Erasmus+ program (https://erasmus-plus.ec.europa.eu/).
Below you’ll find information about current searches at the PhD, Postdoctoral level or with any time of qualification!
 

Selezione pubblica, per titoli e colloquio, per il conferimento di un assegno di tipologia Professionalizzante per lo svolgimento di attività di ricerca inerente all’Area Scientifica Area Scientifica 05 Scienze biologiche e all’Area Scientifica 06 Scienze mediche , presso la sede di Pisa per la seguente tematica: “Metagenomica applicata alle scienze della nutrizione”, sotto la responsabilità scientifica della Dr.ssa Carlotta De Filippo.

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Prof. Kürşad Turgay, an independent research group leader at the Max Planck Unit for the Science of Pathogens (MPUSP), is seeking a PhD student or a Postdoctoral Researcher with excellent skills and knowledge in molecular biology, biochemistry and microbiology. Experience in the field of bacterial stress response and regulation or protein homeostasis would be helpful.

Prof. Turgay´s group focuses its research on bacterial stress response and protein homeostasis mostly in the Gram-positive model organism Bacillus subtilis. Research topics include stringent and heat shock response, the role and function of bacterial chaperone systems such as AAA+ protease systems and their adaptor proteins in protein quality control and regulatory proteolysis, as well as general cellular mechanisms allowing the adaptation of bacterial cells to different environments and stress conditions. In this project we are interested to examine the function and role of AAA+ protease complex ClpCP with its adaptor protein and protein arginine kinase McsB, to study the interplay between protein modification and protein homeostasis.

Prof. Turgay’s group applies a wide range of methods and experimental approaches based on biochemistry, genetics, molecular biology, microbiology and cell biology. Therefore experience in protein purification, molecular biology, fluorescence microscopy and also with data analysis of experiments using modern sequence technologies (NGS) would be helpful. Prof. Turgay’s group is fully embedded within MPUSP and benefits from access to and interactions with various research platforms providing support for state-of-the-art proteomics and genomics experiments as well as the overall infrastructure and environment for MPUSP biologists.

MPUSP is an international research institute of the Max Planck Society located in Berlin and headed by Prof. Emmanuelle Charpentier. The institute was founded in 2018 with the mission to strengthen fundamental research on pathogens causing diseases in humans. MPUSP aims to achieve a better understanding of the complexities of pathogens and their interactions with their natural environment by developing innovative approaches (www.mpusp.mpg.de). The institute offers an interactive and dynamic environment where our team of international and creative scientists are provided ongoing support to take on original research projects and answer free-minded basic biological questions. Our scientists benefit from a state-of-the-art infrastructure, integrative and customdesigned research platforms and a wide range of scientific activities. MPUSP emphasizes personal development: junior and senior scientists at MPUSP are engaged in research, but also take active part in scientific education, mentoring and teaching, and in the management and development of the institute.

We are seeking a highly motivated and talented scientist who has prior experience working with bacteria and demonstrated proficiency with some of the mentioned experimental approaches to join the team of Prof. Turgay.

Please contact Prof. Kürşad Turgay for specific questions regarding this position (turgay@mpusp.mpg.de).

Your qualification should include:
• A Master’s degree (or comparable) and/or a PhD in Biochemistry, Cell Biology, Genetics, Microbiology and/or Molecular Biology or related disciplines
• Proficiency of English language (presentation and writing skills)
• Experience working abroad is considered as an advantage
• Applicants for the postdoc position should have a proven record of successful publications in highly respected international scientific journals
• Friendly disposition, confident and responsible work ethics
• Working independently and as part of an international team
• Self-motivated and enthusiastic to work in a competitive, dynamic, stimulating and interacting international scientific environment focusing on basic biological research

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